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Clinical applications

kidney transplantation

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Clinical applications

kidney transplantation​

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Providing a correct diagnosis of kidney transplant rejection remains a challenge and requires invasive technologies.

KIDNEY BIOPSY : The collection of a small sample of the transplanted kidney to determine the presence of lesions, their types and confirm a rejection episode. Like all surgical procedure, it can lead to serious complications (10-15% cases), and thus is not used routinely.

Schéma d'une biopsy
https://www.mayoclinic.org/tests-procedures/kidney-biopsy/multimedia/kidney-biopsy/img-20005863.

clinical applications

know more about kidney transplantation

Schéma d'une biopsy
https://www.mayoclinic.org/tests-procedures/kidney-biopsy/multimedia/kidney-biopsy/img-20005863.

EPIDEMIOLOGY

Number cases


Europe

New kidney graft
0
Patients with a transplanted kidney
0

USA
New kidney graft
0
Patients with a transplanted kidney
0

Proportion of kidney transplant rejection

Rejection after 1 year
0 %
Rejection after 5 years
0 %
Rejection after 10 years, between
30 %

Value of monitoring damaged kidney cells during an episode of transplant rejection.

Depending on the kidney cells damaged during the rejection episode, the kidney failure will be different and its medical management also. Kidney failure can be classified into 4 categories : Fibrosis, vascular, tubular and glomerular.

A kidney biopsy has to be performed to put the precise diagnosis of the kidney failure during a rejection episode.

Personalized the anti-rejection therapy to improve the patient clinical outcome.

Immunosuppressive drugs are frequently used to prevent acute and chronic rejection of the transplanted kidney. A plentiful of immunosuppressive drugs are available today but providing the optimized therapy to prevent rejection remains a challenge.

By being able to monitor early lesions of the kidney graft allows the medical examiner to modulate the therapy and prevent rejection.

A kidney transplant patient journey today

Urinary and blood test consists in quantifing biomarkers reflecting the functionality of the kidney (creatinine, Glomerular filtration rate…).

They are performed at different frequency according to standardized guidelines :

  • 2–3 times weekly for the first month after transplantation
  • 1–2 times weekly for months 2–3.
  • Every 2–4 weeks for months 4–6.
  • Every 4–6 weeks for months 6–12.
  • 3–6 monthly thereafter.

    • The analysis takes less than 12h.     Pharmacodynamic of the anti-rejection drug is assessed according to standardized guidelines:

  • 2–3 times weekly for the first month after transplantation.
  • 1–2 times weekly for months 2–3.
  • Every 2–4 weeks for months 4–6.
  • Every 4–6 weeks for months 6–12.
  • 3–6 monthly thereafter.
    •

    Kidney biopsy is the gold standard for the diagnostic of kidney graft rejection.

    This analysis consists in quantifying, at cellular level, kidney lesions and analyzing immune cells and anti-HLA antibodies infiltrating the kidney graft.

    Solid kidney biopsy is performed at least one time during the first year (screening biopsy) and for each suspicious urinary & blood tests (up to 2-3 biopsies for patients facing a kidney biopsies).

    The analysis takes between 7 and 21 days.

    Pharmacological study
    Anti-rejection therapy

    Pharmacodynamic of the anti-rejection drug is assessed according to standardized guidelines :

    2–3 times weekly for the first month after transplantation.

    1–2 times weekly for months 2–3.

    Every 2–4 weeks for months 4–6.

    Every 4–6 weeks for months 6–12.

    3–6 monthly thereafter.

    Urinary & Blood test

    Urinary and blood test consists in quantifying biomarkers reflecting the functionality of the kidney (creatinine, Glomerular filtration rate…).

    They are performed at different frequency according to standardized guidelines :

    2–3 times weekly for the first month after transplantation.

    1–2 times weekly for months 2–3.

    Every 2–4 weeks for months 4–6.

    Every 4–6 weeks for months 6–12.

    3–6 monthly thereafter.

    The analysis takes less than 12h.

    Solid Kidney Biopsy

    Urinary and blood test consists in quantifying biomarkers reflecting the functionality of the kidney (creatinine, Glomerular filtration rate…).

    They are performed at different frequency according to standardized guidelines :

    2–3 times weekly for the first month after transplantation.

    1–2 times weekly for months 2–3.

    Every 2–4 weeks for months 4–6.

    Every 4–6 weeks for months 6–12.

    3–6 monthly thereafter.

    The analysis takes less than 12h.

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    CGenetix develops the new generation of liquid biopsy biomarkers to evaluate organs damages during a pathological process.

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