Epigenetic variation on genomic DNA is a key component to regulate a gene in mammalian cell. This biological and molecular parameter contributes with proteins to gene expression and cellular differentiation.
Recently, specific epigenetic patterns finding on circulating cell-free DNA has been investigated by scientists.

In 2018, Moss et al. has proposed a deconvolution model allowing to identify the major contributor of circulating cell-free DNA in healthy subject. Epigenetic molecular screening approach on circulating cell-free DNA promises a large variety of clinical application.